Moyes' first league game in charge of United will be at the LibertyStadium in Saturday's tea-time kick-off.
With Swansea having produced two encouraging performances in their Europa League tie against Malmo, and having spent well during the transfer window, many are predicting a difficult start for Moyes as he takes on the unenviable task of succeeding Sir Alex Ferguson.
The former Everton boss said it was "hard to believe" United's opening five games also include fixtures against Chelsea, Liverpool and Manchester City.
But Laudrup has pointed out that no side welcomes the task of facing United, regardless of the time of the season.
He said: "I have to be careful when people say this is a good time for us to play United. We could lose 3-0 on Saturday.
"There is never a right time to play a team like United because of the quality they have.
"But we have to play them at some stage and I suppose at the beginning of the season it is not too bad.
"I look at their XI and who could play and whatever they do they have a really strong squad.
"Anything is possible when you play them. But we have to play all the big teams and it is not too bad to play them now than in October.
"But it is still difficult, so don't laugh at me if they beat us on Saturday."