City's third attempt to make an impact in Europe's top competition began in impressive fashion in the Czech Republic with a convincing 3-0 defeat of minnows Viktoria Plzen.
The result was the perfect morale boost after a sequence of indifferent performances in the Barclays Premier League and with arch-rivals United due to visit the Etihad Stadium on Sunday.
Kompany, who made an impressive return from a groin injury against the Czech champions, said: "Until now the derby was not a priority at all but obviously now it is the next game.
"We will make sure we are in the right condition for the game.
"It is a special game. It is becoming one of the most sought-after fixtures in the world and it is always great to be involved in such games. I never take them for granted."