The trio were part of Chelsea's 25-man playing party which travelled to Holland for tomorrow's match at the Amsterdam ArenA, the Blues confirmed on their website.
Terry (ankle) and Hazard (hamstring) suffered injuries in Saturday's Premier League win at Aston Villa.
Terry missed last season's Champions League final win in Munich through suspension and his injury means he faces further continental disappointment.
The 32-year-old former England captain's place in the side was already in doubt in a competitive position in central defence, with David Luiz, Gary Cahill and Branislav Ivanovic the Blues' other options.
The loss of Belgian playmaker Hazard would be more keenly felt as they go in search of back-to-back European trophies.
Coupled with the concern over Mikel, who has a hip problem, it may mean Frank Lampard is included, in all likelihood as captain.
Lampard, who became the club's record goalscorer by netting twice in the win at Villa Park, could be deployed in a deep midfield role alongside Luiz, with Ramires pushed further forward alongside Juan Mata and Oscar.
Ryan Bertrand, Ashley Cole's left-back deputy, was also on the short flight from London despite a recent knee injury.