On-loan QPR striker Hewitt scored the winner against Scunthorpe when the Shakers last claimed three points, five npower League One games ago at Scunthorpe.
For the last two matches, the 22-year-old has had to be content with a place on the bench on account of David Healy's return from injury, but he replaced the veteran Northern Ireland international after 54 minutes when Kevin Blackwell's side came back to snatch a dramatic 2-2 draw against Shrewsbury on Friday night.
Blackwell is without Gregg Wylde after the winger's one-month loan spell from Bolton expired - a factor that may see Tom Soares return to the starting line-up.
Bury last met Preston a week ago in the Northern Area quarter-final of the Johnstone's Paint Trophy, losing on penalties after a heated 3-3 draw that caused significant ill-feeling between Blackwell and counterpart Graham Westley.
Defenders Adam Lockwood (groin) and Phil Picken (knee) are long-term absentees, while Andy Bishop remains sidelined with a foot problem.