The Welsh club face the challenge of combining their Europa League campaign with their domestic duties this term, and the St Mary's encounter will be their seventh game in 20 days.
While results have been good in continental competition - Swansea are top of Group A with two wins from two - a difficult run of Barclays Premier League fixtures has seen them suffer three defeats from their first half a dozen games.
The Swans have yet to find the consistency of performance that helped propel them to a ninth-place finish and Capital One Cup success last season, but Dyer does not reckon that is down to manager Michael Laudrup tinkering with his team.
"It's not that hard because we all know the style and the philosophy of our play and our roles in it," he said.
"We are training with each other - we know how to slot in and we can gel quickly.
"Our style helps us do that. It helps that anyone can come into the side and help the team.
"But there's still competition and everyone who comes off the bench or comes into the side gives it their all because you have to be on top form or you may not get a look in."
The former Southampton winger also insists there are no individual frustrations down to the need for players' workloads to be managed.
"It's not about you. You can't go into games wondering if you're starting or not because you're head can go down if you're not," he said.