The striker bagged his 21st goal of the season to seal Saturday's 2-1 victory at Scunthorpe, for whom he registered 11 of those having spent the first half of the campaign on loan with the Iron prior to his January switch to the Sky Blues.
Clarke subsequently left Glanford Park wearing a protective boot over his foot having taken a knock during the game and he will now be assessed ahead of the clash against the U's.
Saturday's success came in boss Steven Pressley's first match at the helm following his appointment 24 hours earlier and he can now look forward to his first outing at the Ricoh Arena.
City have struggled for home form this season, winning just five times compared to a club-record 11 on their travels, and Pressley must reverse that trend if he is to have any chance of closing the five-point gap on the play-off places.
Defenders Richard Wood (groin) and Blair Adams (knee) as well as striker Stephen Elliott (knee) remain sidelined.