The defender suffered a rib injury during the second half of Saturday's 2-0 win at Shrewsbury and was replaced by Elliot Omozusi, who made his second appearance since rejoining the club in January.
Omozusi could now start at right-back with Scott Cuthbert reverting to centre-half in place of Clarke.
Strikers David Mooney (thigh) and Shaun Batt (hamstring) missed out at the weekend and will be checked over, while defender Gary Sawyer and goalkeeper Lee Butcher (both knee) are still on the sidelines.
Midfielders Martin Rowlands and Jimmy Smith could return to the starting line-up if boss Russell Slade opts to make changes for their third game in seven days.
