Wyke only joined the club on loan from Middlesbrough yesterday but he scored one goal and made another as the visitors comfortably claimed their first win in eight matches.
Ardley said: "He's had limited training over the Christmas period with him being an under-21 player as they get a little more time off.
"That was a concern but I said to him 'I'm going to take a risk and throw you in, just run around and then I'll bring you off.'
"First half, there was a little bit too much to feet and we didn't run behind enough but in the second half we did that in abundance and we caused them a shed-load of problems.
"One thing I noticed about Charlie on Friday when we watched him was that he is excellent technically.
"My concern was his fitness levels and the pace of the game and first half I thought that it was a little bit too quick for him.
"But second half, he somehow found something from somewhere and upped it because he was phenomenal - he's got a goal and an assist."
Wimbledon went ahead after 52 minutes when Wycombe failed to clear Sammy Moore's free-kick after Harry Pell headed it down, leaving Wyke with a simple finish.
The Dons effectively sealed the result when Wyke controlled Anthony Stewart's header before setting up Moore, who rolled his shot into the bottom corner.
Jack Midson added a third from the penalty spot after Stewart brought down Kevin Saint-Luce and was sent off, before Jim Fenlon saw red late on for a crude lunge on Josh Scowen.
Wycombe boss Gareth Ainsworth said: "At half-time I was quite happy with the way things had gone.
"We managed to play through them a lot and had some good possession and then in the second half, from the kick-off, we looked a different side.
"I was not happy with the way that we defended - we looked very deep today and we didn't squeeze up often enough.
"They punished us in the second half and it was a very disappointing performance from us.
"I was surprised with our lack of reaction to their opening goal because something we pride ourselves upon is being passionate and having a desire.
"It just went missing today and I'm flummoxed to say why it was missing, but there will be no way it will be missing next week.
"We've got to work hard now because otherwise we're going to be sucked into a nasty situation at the bottom and I don't want that."