Manchester City striker Sergio Aguero (hamstring) will miss out but controversial forward Mario Balotelli is available after recovering from a virus.
Demba Ba is poised to make his Chelsea debut after completing his move from Newcastle. Ba could replace Fernando Torres up front.
Match-by-match team news including Tottenham v Coventry, Fulham v Blackpool and Bolton v Sunderland.
Phil Jones and Nemanja Vidic are set to bolster Manchester United's defence, but Wayne Rooney (knee) has been ruled out for a further two weeks.
Michu is fit and raring to go after playing 90 minutes against Aston Villa while Arsenal reported no fresh injury problems.
Liverpool left-back Jose Enrique has been ruled out for six weeks but Daniel Sturridge could make his debut following his £12m move from Chelsea.
Everton manager David Moyes will try to freshen up his side. Left-back Leighton Baines could be in line for a rest as Bryan Oviedo may be given a run out while midfielders Thomas Hitzlsperger and Ross Barkley may come into contention.