After beating Petrolul Ploiesti of Romania in a two-legged play-off, Michael Laudrup's Capital One Cup champions Swansea have earned the right to play Primera Division giants Valencia, Kuban Krasnodar of Russia and Switzerland's St Gallen.
Winger Pablo Hernandez returns to the Mestalla while Chico Flores, Michu and Jordi Amat are just a few former La Liga stars plying their trade with the Swans.
Spurs - quarter-finalists last season - knocked out Dinamo Tbilisi on Thursday night in the qualifying stage and will meet Anzhi Makhachkala, who have recently sold high-earners Willian, Christopher Samba and Samuel Eto'o after a massive cut in their budget.
They will also venture east to Moldova for a meeting with Sheriff Tiraspol and to the Arctic Circle outpost of Tromso in Norway - the side who have replaced Besiktas in the tournament after the Turkish club's European ban was upheld.
Championship side Wigan, who qualified after winning the FA Cup last season, will take on Rubin Kazan, Slovenian club Maribor and Zulte Waregem of Belgium.
The group stage commences in September.
Group A: Valencia, Swansea, Kuban, St Gallen
Group B: PSV, GNK Dinamo, Chornomorets, Ludogorets,
Group C: Standard Liege, FC Salzburg, Efsborg, Esbjerg
Group D: Rubin Kazan, Wigan Athletic, Maribor, Zulte Waregem
Group E: Fiorentina, FC Dnipro, Pacos Ferreira, Pandurii
Group F: Bordeaux, APOEL, Eintracht Frankfurt, Tel-Aviv
Group G: Dynamo Kiev, Genk, Rapid Wien, Thun
Group H: Sevilla, Freiburg, Estoril, Liberec
Group I: Lyon, Real Betis, Guimaraes, Rijeka
Group J: Lazio, Trabzonspor, Legia Warsaw, Limasol
Group K: Tottenham Hotspur, Anji, FC Sheriff, Tromso
Group L: AZ, Paok, Maccabi Haifa, Shakhter