Ramos was in charge of Spurs for just under a year from October 27, 2007 before being sacked with the club bottom of the Premier League in the 2008-09 season having taken just two points from their opening eight matches.
He will therefore be intent on gaining a measure of revenge over his former side, who announced the sacking of Andre Villas-Boas on Monday morning despite the Portuguese overseeing a 100 per cent record in Europe this season.
Michael Laudrup's Swans, meanwhile, will be tested right from the beginning of their knockout stage crusade by Rafael Benitez's Napoli, who came within a whisker of pipping Arsenal to the Champions League round of 16.
Serie A champions Juventus were disappointed not to progress in the Champions League in what was a disappointing start to the European season for Italian sides, but will begin their attempt to end the season with some sort of Euro silverware against Trabzonspor – Turkish compatriots of Galatasaray, the side who sent Juve packing amid controversy last week.
Lazio will meet Ludogorets Razgrad and Fiorentina start with a trip to Esbjerg, while in other notable European fixtures Porto meet Eintract Frankfurt, Ajax play Red Bull Salzburg and Sevilla play Slovenians Maribor, the team who eliminated Championship side Wigan.
Valencia will play Dynamo Kiev while two Champions League dropouts in Shakhtar Donetsk and Viktoria Plzen were drawn together.
Last 32 draw in full
Real Betis-Rubin Kazan
Last 16 draw in full
Liberec-AZ versus Anzhi-Genk
Lazio-Ludogorets versus Dynamo Kyev-Valencia
Porto-Eintracht Frankfurt versus Swansea-Napoli
Chornomorets Odesa-Lyon versus Plzen-Shakhtar Donetsk
Maribor-Sevilla versus Real Betis-Rubin Kazan
Dnipro-Tottenham versus PAOK-Benfica
Maccabi Tel-Aviv-Basel versus Ajax-Salzburg
Juventus-Trabzonspor versus Esbjerg-Fiorentina