The 18-year-old, host of reality television show Splash!, began his road to Barcelona, where he will gun for World Championships glory this summer, with another success in Plymouth.
Olympic bronze medallist Daley finished over 125 points above his fellow competitors with a final score of 501.00.
James Denny came second with 374.90 and Daniel Goodfellow rounded out the podium with 340.25.
Though his overall total was considerably less than his 556.95 at London 2012, the teenage star was pleased with his performance.
"It wasn't too bad a start to the season - both my performances were over 500 which is all I can ask for really," Daley told British Swimming's official website.
"I've been trying to overcome a chest and throat infection to compete here and it could've been a little bit better. There are a few tweaks I can make and hopefully it will come together later in the season.
"To get the world title back would be the ultimate dream this season - that would be amazing. But it's about working on consistency because everyone is learning lots of harder, new dives."
Elsewhere on Sunday’s bill, Grace Reid won her maiden national title in a senior individual discipline with success in the 3m springboard.
Grace Reid won her first senior individual title with a victory in the 3m springboard while Alicia Bragg, who had already won the 1m springboard and 3m synchro national titles, claimed second ahead of Rebecca Gallantree.
“The tension was building up through the rounds and there was a lot of pressure on that last round,” said Reid.
“I’ve been to a few internationals so I know how to cope and my coach definitely helped me through it but I was shaking at the end.
“This morning I was doing a couple of harder dives but we decided to change that for this final and it’s worked in my favour.
“Sometimes it doesn’t work like that in sport but it’s paid off for me.”
Matthew Roberts and Yona-Knight Wisdom took gold in the men’s 3m synchro.
