The event, which will take place between April 19-21 at the Royal Commonwealth Pool, will mark Daley's first return to international action since winning 10m platform bronze at London 2012.
Beijing and Dubai are the scene for the first two Diving World Series events, but Daley is not among the six-strong team for these two openers which get underway this weekend in China.
Instead the 18-year-old will wait until Scotland to renew his rivalry with China's Qui Bo, who won silver at the London Olympics.
Daley will be joined north of the border by Olympic finalists Tonia Couch, Sarah Barrow, Nick Robinson-Baker, Chris Mears, Alicia Blagg and Hannah Starling – with the latter four travelling to Beijing and Dubai.
"The World Series is a great way to start the season," said Daley. "It allows us to compete against the best ahead of the World Championships and it is a good measure of how you are doing in mid season training.
"At the beginning of the year my coaches and I decided that I wouldn't compete in all six legs of the World Series.
"We have chosen the most important competitions for me to focus on. This event is going to be used as part of the qualification for the Worlds so I am looking to put in a good performance in Edinburgh.
"I'm really looking forward to the World Championships this year which is the first major competition for me after the Olympics. It will be a challenge because Bo has always performed well at this level but I am working hard and I will see what I can do.
"I'm really excited to be getting back into the competitive season. I have never competed inEdinburgh before and from what I have seen the pool looks great. It is exciting to think that this pool will be used for the Commonwealth Games.
"It is always good to have the support from your home crowd and that definitely inspired me in London and I hope it will inspire the whole team in Edinburgh too."
Mears, who finished ninth at the London Olympics, added: "I’m really proud of my performance at the Olympics. Making the final was beyond my expectations and something I'll never forget.
"Competing in front of a home crowd was like nothing I had experienced before and I think that the crowd in Edinburgh will create a great atmosphere and spur us all on to do our best.
"I will be in the Synchro and the Individual and I know the competition will be tough but I have been working on new dives which I can’t wait to showcase in front of the crowd."