Eurosport - Michael Van Staeyen (Imago)
The Belgian held off Frederique Robert of Lotto-Belisol and Justin Jules of La Pomme Marseille in the race to the line in Beaucaire.
The 24-year-old Topsport Vlaanderen-Baloise rider has not won a stage since 2011, but now holds the lead of the five-day race.
The race continues with a 157km route from Nimes to Allegre les Fumades.
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