La Provence report that the third stage, set to finish in Saint Remy de Provence, could not be secured and with no alternate route available, the decision was made hours after Lars Boom had claimed the leaders jersey with victory in stage two.
"There are logistical problems beyond our control," said the race organisation.
Blanco Pro Cycling rider Boom moved into the overall lead with success in Thursday’s 24km time trial from Cap d’Agde with a climbing finale. He leads RadioShack Leopard’s Maxime Monfort by 22 seconds.
The Tour will resume on Saturday with what was scheduled to be the fourth stage, a 151km trek from Rousset to Toulon featuring a mountain-top finish at Mont Faron.
The conclusion takes place on Sunday with a 192km stage from Bandol to Grasse.