The women's team pursuit trio of Joanna Rowsell, Laura Trott and Dani King won world and Olympic gold this year in a remarkable run that saw them break the world record six successive times.
But that sequence will come to an end this weekend with Rowsell missing the trip to Scotland's capital, and the first competition to take place at the new Sir Chris Hoy Velodrome, having recently been laid low with a virus.
Trott is poised to take the lead role with King second and the third place goes to 18-year-old Barker, who already holds world junior road time-trial and junior European individual pursuit titles.
Barker's prowess on the track and road means she could have a tough decision to make in the future as to where her plans lie, but for the immediate future the Cardiff cyclist is only focused on making a good impression in Glasgow.
"It's a massive opportunity," Barker said.
"I've got the best in the world to try to keep up with.
"At the moment I'm still really young. I'm lucky enough to do track and road, but when I get older I'm going to have to specialise."