RCS Sport handed the first ever professional team from Africa a place, along with the top 18 teams in the world, in both races.
Team NetApp-Endura, Katusha and Vini Fantini will also contest Tirreno-Adriatico with Androni Giocattoli, Bardiani Valvole-CSF Inox, Iam Cycling and Europcar joining the latter two teams in La Primavera.
MTN-QhubekaTeam principal Douglas Ryder said: "It was a major goal for us this year to get into those two races as they are two of the most prestigious ones on the calendar.
"Tirreno-Adriatico will offer some tough stage racing while Milan-San Remo at almost 300km long will offer our riders a great learning opportunity in tough one-day classic conditions."
Team captain Gerald Ciolek added: "I've been building the early part of my season around these two races. To have them confirmed for our team is great.
"People may have wondered why I signed for a Pro Continental team but I think everyone is starting to believe why this project is so special. I am looking forward to heading to Italy for these races."
Tirreno-Adriatico begins on March 6 while Milan-San Remo, one of the sport's most-prestigious one-day races, takes place on March 17.