The 29-year-old, who made 37 appearances for his homeland before switching allegiance, is one of three new caps in the England side at Malahide.
Hampshire batsman Michael Carberry, who played one Test match against Bangladesh three years ago, and Yorkshire's Gary Ballance will also make their first ODI appearances.
England, captained by another Irishman in Eoin Morgan, who won the toss and chose to bowl first, left out Danny Briggs, Chris Jordan and Jamie Overton from the squad available.
England are resting a host of players after their summer Ashes exertions, including regular skipper Alastair Cook.
Three of them - Kevin Pietersen, Joe Root and Jonathan Trott - are due to link up with the squad for Friday's first one-dayer against Australia at Headingley.
Ireland's side included a former England player in Sussex batsman Ed Joyce.