Having won the first match with a six-wicket victory on Wednesday, Ireland looked on course for a record-breaking triumph when they limited the reigning World T20 champions to 96 for nine at Sabina Park.
Seamer Alex Cusack claimed superb figures of four for 11 - including a rare maiden over in this format - as six Windies batsmen got into double figures but none of whom managed to get into the 20s.
However, with history within their sights, Ireland could not get over the finishing line, making only 85 for eight in reply as the Windies bowlers held their nerve in a nail-biting run chase to secure an 11-run win and tie the two-match series 1-1.
Ireland never recovered after slumping to 29 for five with captain William Porterfield, Ed Joyce and the big-hitting Kevin O'Brien among those out.
Wicketkeeper Gary Wilson gave Ireland a glimmer of hope with 35 off 39 balls to edge his side closer to their target, but when he was the seventh wicket to fall in the 18th over, caught and bowled by Dwayne Bravo, the tourists' bid was all but over.
Captain Darren Sammy took three for 22 for the hosts while Krishmar Santokie, Samuel Badree and Sunil Narine all bowled miserly spells to save the Windies from embarrassment.
That did not look like being the case earlier in the evening as they failed to reach three figures after being send into bat, with Andre Fletcher top-scoring with only 19.