A team minus captain Alastair Cook, his one-day international opening partner Ian Bell and frontline bowlers James Anderson, Stuart Broad and Graeme Swann came unstuck in an 88-run defeat against Australia at Old Trafford.
The same experimental line-up, give or take the possible inclusion of one emerging player for another under stand-in captain Eoin Morgan, must therefore try to battle back from 1-0 down with three to play at Edgbaston.
Vaughan responded to the announcement of England's squad, and before Australia went on to pile up 315 for seven in Manchester against an attack featuring only three tried-and-tested specialist bowlers, by calling for a minor reimbursement for anyone who thought the event might have been mis-sold.
Asked about the opinion voiced by his former Test captain, England's limited-overs coach said: "It's harsh - I think it was said in haste by Michael."
Giles can hardly argue over the absence of almost half the team who can reasonably be expected to represent England at the next World Cup in Australia and New Zealand in 2015, but added nonetheless: "This is an exciting side to come and watch.
"(There's) Kevin Pietersen; Michael Carberry is an exciting batsman at the top of the order; then you go (Jonathan) Trott, (Joe) Root, Morgan, (Ravi) Bopara ... (Steven) Finn - there are some good names to watch.
"Then you have the youngsters.
"I'd hope the cricketing public would want us to bring through some of our young cricketers and expose them to what is almost the harshest of environments, which is playing Australia."