The two sides meet again in Saturday's Twenty20 semi-finals - and bowler Jade Dernbach is anxious to lay down an early marker as Surrey attempt to rescue a disappointing season with some silverware.
Dernbach is convinced that a successful Twenty20 finals day would also boost Surrey's bid to avoid relegation from the first division of the LV= County Championship.
"It's interesting (playing Hampshire) two days before the semi-final," said Dernbach, an England limited overs international.
"It gives players a last chance to see what other players are doing and where their minds are. It could be an edgy type of game.
"It could leave the door open for us to get a result and you never know what sort of damage that might do mentally.
"Winning is a habit and we have got into that habit. If we end up winning a trophy on Saturday it will boost the boys confidence for the last six weeks. If we get on a roll and shoot up the table, then the whole season looks different."
Dernbach traces the upturn in Surrey's confidence to the start of the Twenty20 campaign and the arrival of Alec Stewart as coach, in place of Chris Adams.
"It was a very difficult start to the year but the Twenty20 came at a perfect time, to break from the first half of the season," Dernbach said.
"That is when we lost Chris Adams and Ian Salisbury (as coaches). Since Stewey came in there has been a whole new feel. The boys have been lifted."
Surrey's season has mirrored Dernbach's to a large degree. The 27-year-old found himself dropped by England but returned to the county game, worked hard and now feels in prime form.
With Twenty20 and one-day internationals to come after the Ashes, Dernbach has his own personal motivation for performing well at Edgbaston.
"It is obviously disappointing to be dropped when you have been in the national set-up. You can fall into the trap of feeling sorry for yourself but it is about how quickly you bounce back," Dernbach said.
"International cricket is an unforgiving environment. I was very motivated to come back to Surrey and do well.
"I have honed my skills, practised my variation and my death bowling. I am in a good frame of mind."