It will be the first time that Anton Ferdinand and John Terry have met on a football pitch since the Chelsea captain was cleared of using a racial slur against Ferdinand.
QPR boss Mark Hughes again insisted that he will not force anybody to shake hands, and is happy to leave the matter in the hands of his players.
"We've had a discussion with the players but that's between myself and them,” Hughes said. “We don't have to broadcast that.
"We'll have to wait and see (if Ferdinand shakes Terry's hand). Everybody has a mind of their own and will make a personal decision.
"It's unfortunate that they're in a situation where it's in the public domain. Anton is fine, there's no problem with him."
In contrast, Chelsea boss Roberto Di Matteo insisted he wants his team to follow the direction given by the Premier League.
"I hope that they will respect the rules and go ahead with it and we can all focus on the football," he said.
"Hopefully, everybody will focus on football ... and move on. The Premier League is watched all over the world now and we have to set a good positive standard for everyone watching."
Earlier, the Premier League had revealed in a statement that the pre-match handshake would not be scrapped, as it was in the last meeting between the sides.
It said: "There has been dialogue between the Premier League, Queens Park Rangers and Chelsea in relation to the match between the two clubs.
"All parties understand and acknowledge that the pre-match handshake will go ahead as part of the normal pre-match activity."