Wayne Rooney was among those to miss out, even though he was able to return to training after sitting out the weekend defeat at Norwich with tonsillitis.
With qualification already secured, Ferguson also left out Rio Ferdinand, skipper Patrice Evra and top scorer Robin van Persie among those not to make the trip.
Paul Scholes was absent too, as was Ryan Giggs, the only survivor from that 1993 'Welcome to Hell' expedition to Istanbul, was omitted following his appearance at Carrow Road.
Although they are through midfielder Michael Carrick has no intention of spending the week trying to work out who they may play next.
"You can drive yourself mad thinking about who you might get and all the various permutations," he said. "We just have to win our games, which we have done, and see what the draw gives us. Whoever it is, we will be ready in February."
In recent years, United have done rather well in the knockout stages of the competition too, reaching three finals, a semi-final and a quarter-final on the last five occasions they have progressed beyond the group phase.
"That is the big test," said Carrick. "That is when the competition really comes alive.
"We have done the first part. The second one is when we get the really big European nights and we go away to the best places in Europe and win games.
"We have managed to do that very well over the past few years. Hopefully we can get back to that."
Full squad: Sam Johnstone, Anders Lindegaard; Rafael, Alexander Buttner, Phil Jones, Tom Thorpe, Marnick Vermijl, Scott Wootton; Michael Carrick, Davide Petrucci, Larnell Cole, Tom Cleverley, Darren Fletcher, Anderson, Nick Powell, Ashley Young, Ryan Tunnicliffe; Javier Hernandez, Joshua King, Danny Welbeck, Federico Macheda.