Carlos Martins sustained a thigh problem against Vitoria de Guimaraes at the weekend, while Nemanja Matic is suspended for Jorge Jesus's side. Andre Gomes, the promising 18-year-old midfielder, may get a start in midfield, while Luisiniho is expected to continue at left-back.
Juan Insaurralde and Artem Dzyuba are both back in contention for the visitors after servicing a suspension and recovering from illness, respectively; but there is still no sign of Aiden McGeady returning after sustaining a foot injury.
Jorge Jesus: "The game against Spartak should have characteristics different from those of normal. I admit that I myself still have that doubt. Sometimes selection points are most important for my decisions, but still I have a doubts."
Unai Emery quotes to follow...
After a run of only one defeat in 17 home games in Europe, Benfica have lost the last two.
Benfica have won three and lost none of their five home games in Europe against Russian opponents and conceded just one goal in total.
Spartak have scored in each of their last 10 European away matches.
Benfica have lost four and won none of their last five Champions League matches and scored just two goals in that run.
The Portuguese side have not gone six without a win in Europe since September 2003.
Benfica have committed 53 fouls, more than any other team in the Champions League.
Following a run of 12 consecutive defeats away from home in the Champions League, Spartak have won three and lost two of the last five.
Spartak have drawn none of their last 30 away Champions League matches, losing 21.
Benfica 4/7 Draw 3/1 Spartak Moscow 5/1