Frampton was on the front foot from the start against a game opponent, and forced the referee to step in during round six to the delight of the partisan crowd.
The win puts 'The Jackal' at 17-0 in what was billed as an IBF super-bantamweight title eliminator. That belt is currently held by Spaniard Kiko Martinez, whom Frampton stopped in his last outing in February.
Injury and a managerial change from Matchroom to Frank Warren - done to allow Barry and Shane McGuigan more control as Frampton's promoters - caused the eight-month gap in the 26-year-old's schedule, during which Martinez became champion.
In the chief support bout, Eamonn O’Kane overcame a round 10 knockdown to win a 12-round unanimous decision over Kerry Hope in middleweight action.