Burns’s title defence against Liam Walsh was set to headline at London’s ExCeL on December 15 until a car accident sidelined the Rochdale fighter.
Jose Ocampo (17-5-1) was announced as his replacement, keeping the world title top-liner alive, but following the death of his trainer from a fatal heart attack the Filipino has also withdrawn.
Promoter Alex Morrison told STV: "The fight is off. Ocampo's trainer died.
"We're searching for another opponent and we're optimistic we'll get one. However, time will tell if it will be a world title fight.
"It's definitely upsetting for Ricky. He's pretty disappointed.
"First we had an orthodox opponent (Walsh) that got called off. Then a southpaw in Ocampo and Billy Nelson (Burns's trainer) has specifically brought up a southpaw from England for Ricky to spar with.
"So yes, it's pretty upsetting for Ricky. I'm meeting him later this afternoon and hopefully we can get another opponent by close of play today."
Scotsman Burns (35-2-0) will likely fight a low-risk stand-in on Saturday, further damaging his hopes of being prepared for a potential title unification bout with undefeated American Adrien Broner, holder of the division's WBC title.