Zhuang snatched a dramatic final-frame decider over world number 10 Bingham at the Yixing Sports Centre to advance to a last-16 encounter with fellow rank outsider Jin Long.
No upsets were to be found elsewhere as Mark Williams, Matthew Stevens, Barry Hawkins, Marcus Campbell, Ben Woollaston and Stephen Lee all progressed at the expense of amateur opposition, as did home hopes Ding Junhui and Cao Yupeng.
Tom Ford defeated Ricky Walden 4-1 and Robert Milkins edged Mark Davis 4-3 in the two all-English ties, while Joe Perry overcame Welshman Jamie Jones 4-2.
Perry faces Lee, Stevens meets Campbell, Williams is up against Yupeng and Ding plays Ford in selected round four fixtures.
Asian PTC2 Round Three results
Stuart Bingham 3-4 Niu Zhuang
Li Yan 1-4 Jin Long
Li Yuan 1-4 Cao Yupeng
Wang Linhan 2-4 Mark Williams
Ricky Walden 1-4 Tom Ford
Liang Wenbo 2-4 Matthew Stevens
Marcus Campbell 4-2 Zhou Yuelong
Chen Zhe 3-4 Shi Hanqing
Ding Junhui 4-1 Tang Jun
Barry Hawkins 4-0 Zhang Yang
Mei Xi Wen 1-4 Marco Fu
Cao Xin Long 1-4 Xiao Guodong
Ben Woollaston 4-3 Pan Weixing
Mark Davis 3-4 Robert Milkins
Jamie Jones 2-4 Joe Perry
Chen Ruifu 1-4 Stephen Lee
