Fenerbahce overpowered city rivals Anadolu Efes Istanbul 71-63 in the day's other big game and Panathinaikos also claimed local bragging rights in Greece after edging holders Olympiacos 66-62 on Thursday.
Blatt, who guided Russia to the 2007 European Championship and won bronze medals with them at the 2011 tournament and the 2012 Olympics, was awarded the Russian Order of Friendship for his accomplishments and given a standing ovation by CSKA fans before the game.
But that was as good as it got for the trophy-laden 54-year old American as CSKA brushed Maccabi aside in their first meeting since 2010, Serbia playmaker Milos Teodosic scoring a game-high 22 points.
Teodosic hit four three-pointers from five attempts and former Toronto Raptors forward Sonny Weems added 17 as CSKA displayed superior skill and athleticism.
"We missed four players from our regular rotation but I can't use their injuries as an excuse because CSKA played a great game and without question were far better than us tonight," Blatt told the competition's official website.
His counterpart Ettore Messina added: "I wish all of us would stay humble and remember that the road to the Final Four is long and difficult."
The result left CSKA joint top of their section alongside Real Madrid with a 6-1 record, halfway through the second group stage of Europe's premier club competition.
The top four from both eight-team pools qualify for the best-of-five quarter-final play-off series, whose winners will advance to the May 16-18 Final Four in Milan.
Fenerbahce were under pressure to win at Efes in order to keep alive their hopes of reaching the knockout stages and delivered thanks to effervescent performances by forwards Bojan Bogdanovic and Linas Kleiza in a fervent atmosphere.
Efes made a brighter start but Fenerbahce pulled away in the final quarter as Croatian Bogdanovic scored 17 points and Lithuanian sharpshooter Kleiza netted 16, with the duo collecting five rebounds apiece.
Panathinaikos came out on top in a see-saw battle against their bitter foes after outscoring them 11-3 in a frantic finale, with Gabon forward Stephane Lasme amassing 18 points and five rebounds to keep the six-time champions on course for a last-eight berth.
"The result has kept us alive because we would have been in trouble if we had lost this one," said Panathinaikos guard Roko Leni Ukic.
"Now the situation is neither great nor bad, what matters is that in the end we had something more than Olympiacos and beat them."
Panathinaikos, Olympiacos and Spaniards Unicaja Malaga currently occupy three of the playoff berths in their section, behind runaway leaders Barcelona who eased to an 80-68 win at compatriots Laboral Kutxa.
Real Madrid, bidding for a record ninth Euroleague title, also made light work of their 108-72 home victory against Lithuanians Zalgiris Kaunas.