First baseman Teixeira had to pull out of the tournament after straining his right wrist while taking warmup swings before Tuesday's U.S. exhibition game against the White Sox.
Left-handed hitting Hosmer, 23, batted .232 with 14 homers and 60 runs batted in last season with Kansas City, after a sizzling rookie campaign in which he batted .293 with 19 home runs and 78 RBIs.
Hosmer has been off to a hot start in spring training, hitting .391 with four extra-base hits and eight RBIs in nine games.
The U.S. team play their first game in the international tournament in Phoenix on Friday against Mexico.
