Greene has opted out of an indoor season every year since 2007 but, with the 26-year-old looking to defend his outdoor world 400m hurdles title this summer, it's all change.
And Greene will make a step up in distance, lining up in a flat 600m race in Scotland as he represents a Commonwealth Select team set to take on Britain, USA, Germany and Russia.
His last outing over 600m was a year before his last indoor appearance in 2006 where he clocked 1:18.8minutes with Ikem Billy's 28-year-old British record seemingly up for grabs.
Greene, who finished fourth in the 400m hurdles final at the London 2012 Olympics, will need to beat 1:17.6 to do so and he is targeting a fast start with his world title defence in mind.
"This year I will be defending my world title, so it's really important that I hit the ground running with a strong start in Glasgow," said Greene.
"I'm really looking forward to getting a full winter's training under my belt after last year's was interrupted and I'm really excited about competing in Glasgow.
"It will be the first time I have run indoors since 2007, but it will be good to test out my strength over a longer distance and see how I match up.
"After setting a personal best last year, I'm hoping to post a good time in Glasgow to set me up for a big year ahead."
Making the step down in distance to face Greene over 600m in Glasgow will be fellow Brit Andrew Osagie while American Duane Solomon will also be on the start line.
Soloman finished fourth in the Olympic 800m final in London with Osagie, who won world indoor bronze over the distance last year, coming home eighth.
Osagie clocked a personal best of 1:43.77 in doing so and, while he knows he will get another in Glasgow, he insists he won't be holding back.
"I had a fantastic year in 2012. To win a world indoor medal, reach the Olympic final and run a personal best all in the same year was a dream come true," said Osagie.
"I want to kick on and keep this momentum going and the indoor events in the British Athletics Series give me a perfect platform to do just that.
"It's going to be really interesting to test myself in the 600m, it is the first race of the season and shorter than my normal distance.
"But it is great to race over different distances and will give me an idea of where my speed is at, it will be my first time to race a 600m, so I'm sure to get a personal best no matter what.
"The prospect of going up against Dai is also something I'm really looking forward to, so hopefully we can give the crowd a great race."