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Seahawks 23, Texans 20 (OT)
Seattle rallied from a two-touchdown deficit in the fourth quarter to remain unbeaten.
Seahawks kicker Steven Hauschka nailed a 45-yard field goal with 3:19 remaining in the extra session to cap the Seattle (4-0) comeback.
Houston cornerback Kareem Jackson paved the way for victory with a crucial personal foul penalty that gave Seattle the ball at the Houston 36.
Clinging to a seven-point lead, Houston quarterback Matt Schaub threw a pick-6 for a third consecutive week, this time intercepted by cornerback Richard Sherman for 58 yards with 2:40 left in the fourth.
Schaub finished with 355 passing yards and two scores for the Texans (2-2).
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Chiefs 31, Giants 7
Kansas City dismantled New York to improve to 4-0 and keep the floundering Giants winless.
Alex Smith threw for three scores, and Jamaal Charles had 65 yards on the ground and one receiving touchdown as the Chiefs scored 21 unanswered points to complete the rout.
Victor Cruz had 164 yards receiving and a score for New York.
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Vikings 34, Steelers 27
Adrian Peterson rushed for 140 yards and two touchdowns and back-up quarterback Matt Cassel passed for 248 yards and two scores to lead the Vikings to their first victory of the season over the winless Pittsburgh Steelers at London's Wembley Stadium as part of the NFL's International Series.
The Vikings led 34-17 but had to make a last-minute defensive stand to hang on as Everson Griffen sacked Ben Roethlisberger and forced on a third-and-goal play from the six yard line and defensive tackle Kevin Williams recovered with six seconds remaining.
The Vikings improved to 1-3 in large part because they did not commit a turnover with Cassel calling the signals in place of Christian Ponder, who missed the game with a fractured rib.
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Bills 23, Ravens 20
Kiko Alonso made a diving interception of a Joe Flacco pass with 57 seconds to go to preserve Buffalo's upset of Baltimore.
It was Alonso's second interception of the game and the fifth against Flacco, who was the most valuable player in February's Super Bowl.
Baltimore rallied from a 23-14 deficit in the fourth quarter, and receiver Torrey Smith had 166 receiving yards and a score, but Flacco's mistakes doomed them.
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Lions 40, Bears 32
Reggie Bush rushed for 139 yards, including 112 in the opening half, and scored on a 37-yard run as Detroit handed Chicago its first loss.
Matt Stafford passed for 242 yards and a touchdown and also scored by recovering his own fumble as the Lions (3-1) moved into a first-place tie with the Bears (3-1) in the NFC North.
Detroit defensive tackle Nick Fairley added a 4-yard fumble return for a score and David Akers contributed four field goals.
Chicago clawed back from a 37-16 deficit as Jay Cutler tossed two scores in the final minutes but it was too late.
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Browns 17, Bengals 6
Brian Hoyer engineered two long scoring drives that started inside the 10-yard-line and the Browns defense put the clamps on star receiver A.J. Green for a convincing victory over the Bengals.
It was Hoyer's second start after taking over for injured Brandon Weeden. Hoyer threw three touchdown passes last week when the Browns beat the Vikings, and added two in the follow up.
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Colts 37, Jaguars 3
Andrew Luck passed for 260 yards and two touchdowns to lead Indianapolis in a rout of Jacksonville, keeping the Jaguars winless following the AFC South opener for both teams.
Veteran Reggie Wayne started his 186th straight game -- the second-longest active streak in the NFL -- and caught five passes for 100 yards and a touchdown for the Colts (3-1) while Trent Richardson rushed for 60 yards and a TD in his second game since being traded from Cleveland.
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Cardinals 13, Buccaneers 10
Arizona overcame a 10-point fourth-quarter deficit to beat Tampa Bay, handing the Buccaneers their third last-minute loss in a 0-4 start.
Kicker Jay Feely hit a game-winning 27-yard field goal with 90 seconds left, capping off Arizona's final flurry.
The Cardinals scored 10 points in the final four minutes, sparked by the first of two interceptions thrown by Buccaneers rookie quarterback Mike Glennon, who completed 24-of-43 passes for 193 yards and a touchdown in his first NFL start.