Kelly's speedy offense ran 54 plays for 22 first downs in building a 33-7 margin just 1:26 into the third quarter.
Michael Vick completed 15 of 25 passes for 203 yards with two touchdown passes and no interceptions. Vick also ran nine times for 56 yards and a score, augmenting a ground attack that got 31 carries, 184 yards and a touchdown from LeSean McCoy.
Eagles receiver DeSean Jackson caught seven passes for 104 yards and a touchdown.
Meanwhile, as Washington fell behind by 26 points, Griffin began 6-for-14 for 62 yards with two interceptions while running twice for just two yards.
The second-year quarterback led a rally that made the score and his statistics deceivingly respectable. Griffin finished 30-for-49 for a career-high 329 yards with two touchdown passes and the two picks. He ended the night with five carries for 24 yards.
Griffin and Hankerson connected for a 24-yard touchdown with just 74 seconds left to cut the deficit to seven, but the Eagles recovered the ensuing onside kick.
The Houston Texans wiped out a three-touchdown deficit in the second half to earn a victory over the San Diego Chargers in their season opener.
Randy Bullock's 41-yard field goal on the game's final play clinched the win for the Texans and handed the Chargers a bitter defeat. The decisive drive went 38 yards on nine plays.
The Chargers led 28-7 early in the third quarter before the Texans stormed back.
Quarterback Matt Schaub led Houston on a 70-yard drive in 11 plays, hitting Garrett Graham for a seven-yard scoring pass to cut the lead to 28-14 with 5:02 left in the third.
The Chargers began to self-destruct from that point. Schaub threw a nine-yard touchdown to Owen Daniels on the next play to pull the Texans to within 28-21 and Brian Cushing tied the game with 9:30 left when he picked off a Philip Rivers pass and returned it 18 yards.
Schaub finished 34-of-45 for 346 yards with three touchdowns and an interception. Rivers threw four touchdowns, three in the first half, but completed only 14-of-29 passes for 195 yards. He threw four TD passes and the one costly interception.
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