Ahead of the latest instalment on Sunday at Stamford Bridge, we decided to wander down memory lane and revisit some of the best encounters between the two:
United 4-0 Chelsea: FA Cup final, May 14 1994
The first domestic double for Sir Alex Ferguson as Glenn Hoddle's Chelsea were put to the sword by Eric Cantona and friends.
United 1-1 Chelsea (6-5 pens): Champions League final, May 21 2008
It was not as resounding a last-hurdle defeat for the London side in Moscow, but infinitely more heart-wrenching as John Terry's infamous penalty slip helps condemn them to a narrow shoot-out loss.
United 0-4 Chelsea: First Division, August 24 1968
Of United's three European titles, the above 2008 win over the Blues was the only one which didn't see Chelsea absolutely tonk their Northern rivals the following season in the league. Tommy Baldwin netted half the tally in this home humbling for the Red Devils.
Chelsea 5-0 United: Premier League, October 3 1999
And when Fergie's lads completed the treble at the end of the century, they were subjected to another Chelsea pounding shortly afterwards in a Massimo Taibi horror show.
Chelsea 5-4 United: League Cup, October 31 2012
The most recent Chelsea-United stonker produced NINE goals at Stamford Bridge, as the 'inferior' domestic tournament stole the show.
Chelsea 3-3 United: Premier League, February 5 2012
Earlier that year during Andre Villas-Boas' short stint as Chelsea boss, his men watched a three-goal lead slip through their fingers in a thriller overshadowed by the shower of boos launched upon Rio Ferdinand in the wake of the John Terry race row.
Chelsea 3-5 United: FA Cup, January 4 1998
Chelsea were able to pull back three goals when the roles were reversed in this FA Cup classic. Only problem was, United were 5-0 up.
United 1-3 Chelsea: Premier League, May 10 2005
Jose Mourinho had defeated a depleted United 1-0 early in his first season at Chelsea, and his second battle with the Reds in his initial stint saw them break records at Old Trafford on their way to lifting their first Premier League trophy. Sunday is Mourinho's second United fixture of his second Chelsea reign. Omen?
Any other great games between these two sides you wish to recall? Tell us about them in the comments section below.