The San Siro has played host to many great matches over the years, but not often will it have hosted two such mouthwatering clashes in a single week: after the AC Milan v Barcelona Champions League on Wednesday, this Sunday the venerable stadium is the venue for the Milan derby.
Resurgent AC Milan, buoyed up by their win over Barcelona, meet an Inter Milan side mired in a mid-season crisis in Sunday's Serie A derby which also features maverick striker Mario Balotelli facing his former club.
The mood in the two camps could not be more different with Inter, who at one stage were one point behind leaders Juventus, in a slump and their rivals on a high after Wednesday's 2-0 win in the Champions League.
Milan have also enjoyed a resurgence in the league, helped greatly by the signing of maverick striker Balotelli who has scored four goals in three games since his move from Manchester City.
The wildly unpredictable "Supermario" will be facing the club where he spent four seasons and made his top-flight debut.
Inter coach Andrea Stramaccioni has emerged victorious from both his previous meetings with AC Milan and badly needs a third win to rescue his side's season.
The Milan rivals have undergone a role reversal since the start of the year with AC Milan, whose early-season struggles led to weekly speculation over the future of coach Massimiliano Allegri, now ahead of Inter.
Milan have taken 23 points from 10 games since the start of December and are third with 44 points, one ahead of Inter.
Inter have taken 15 points in the same period and have suffered three bad defeats since the start of the season, at Udinese, struggling Siena and a 4-1 thrashing by Fiorentina last Sunday.
Former youth team coach Stramaccioni was promoted to Inter coach late last term and their 4-2 win over Milan ended their rivals' hopes of winning the title. They also won this season's first meeting 1-0.
"The good and bad thing about being coach of Inter is that this pressure is on me from the first day I took charge of this great team," said Stramaccioni.
"If a coach at this level thinks about these things, then he is finished before he even begins," added the 37-year-old.
"There is a lot of pressure, as we lost 4-1 on Sunday and it's only normal to be criticised, but I think we will do well.
"The club is working on the renewal of the team and this is only the first year of that process."
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Reuters / Opta / Eurosport