Two likely title contenders welcome back important players ahead of the latest round of Premier League fixtures, as a raft of deadline-day signings prepare for their debuts.
Chelsea are boosted by Petr Cech's quick return to fitness and the Czech Republic international is expected to reclaim the gloves from Henrique Hilario for Saturday's trip to Sunderland.
The Blues also have young forward Daniel Sturridge available after he completed a three-match ban but concussion rules out Didier Drogba following his nasty fall against Norwich.
Also back from suspension is Kolo Toure as his ban for failing a drugs test is now complete. However, the Manchester City defender is lacking match fitness and may not feature in the home game against Wigan.
City must wait on news of whether a hand injury sustained on international duty will prevent Samir Nasri from continuing his impressive start to life at Etihad Stadium.
Arsenal, who welcome Swansea to Emirates Stadium on Saturday, have Emmanuel Frimpong available again but Carl Jenkinson, Alex Song and Gervinho are all suspended.
The Gunners have also lost Thomas Vermaelen to an Achilles injury and new signing Per Mertesacker is likely to make his debut, along with Mikel Arteta.
Rivals Tottenham have been struck by the news that Netherlands international Rafael van der Vaart has been ruled out with a hamstring injury sustained against Manchester City last time out.