| Date | Race | Stages | Category | Winner |
|---|---|---|---|---|
| 01/04 - 03/04 | Three Days in the Panne | 0 | 2.HC | Joost POSTHUMA (HOL) |
| 01/04 - 06/04 | Semaine lombarde | 0 | 2.1 | Danilo DI LUCA (ITA) |
| 04/04 | Adelie route | N | (1).1 | Kevin ISTA (BEL) |
| 05/04 | GP Miguel Indurain | N | (1).HC | Fabian WEGMANN (ALL) |
| 05/04 | Hel Van Het Mergelland | N | (1).1 | Tony MARTIN (ALL) |
| 06/04 | GP of Rennes | N | (1).1 | Mikhailov KHALILOV (UKR) |
| 06/04 | Tour of Flandres | N | PT | Stijn DEVOLDER (BEL) |
| 07/04 - 12/04 | Tour of Holland-Basque | 0 | PT | Alberto CONTADOR (ESP) |
| 08/04 - 11/04 | Circuit of the Sarthe | 0 | 2.1 | Thomas VOECKLER (FRA) |
| 09/04 - 13/04 | Tour d'Alentejo | 0 | 2.1 | Hector GUERRA (ESP) |
| 09/04 | Gand-Wevelgem | N | PT | Oscar FREIRE (ESP) |
| 10/04 | GP Pino Cerami | N | (1).1 | Patrick CALCAGNI (SUI) |
| 12/04 | Ronde Van Drenthe | N | (1).1 | Coen VERMELTFOORT (HOL) |
| 13/04 | Paris-Roubaix | N | H. | BEL Tom () |
| 13/04 | GP Primavera | N | (1).1 | Damiano CUNEGO (ITA) |
| 15/04 | Paris-Camembert | N | (1).1 | Alejandro VALVERDE (ESP) |
| 16/04 - 20/04 | Tour of Aragon | 0 | 2.1 | |
| 16/04 | GP of l'Escaut-Schoten | N | (1).HC | Mark CAVENDISH (GBR) |
| 17/04 | GP of Denain | N | (1).1 | Edvald HAGEN (NOR) |
| 19/04 | Tour du Finistère | N | (1).1 | David LE LAY (FRA) |
| 20/04 | Amstel Gold Race | N | PT | Damiano CUNEGO (ITA) |
| 20/04 | Tour d'Oro | N | (1).1 | Gabriele BOSISIO (ITA) |
| 20/04 | Tro Bro Leon | N | (1).1 | Frédéric GUESDON (FRA) |
| 22/04 - 25/04 | Tour of Trentin | 0 | 2.1 | Vincenzo NIBALI (ITA) |
| 23/04 | Wallonne arrow | N | H. | LUX Kim () |
| 27/04 | Liège-Bastogne-Liège | N | H. | ESP Alejandro () |
| 29/04 - 04/05 | Tour of Romandie | 0 | PT | Andreas KLODEN (ALL) |